Arctigenin attenuates CCl4-induced hepatotoxicity through suppressing matrix metalloproteinase-2 and oxidative stress

Abstract Background In spite of the huge advances in recent medicine, there is no effective drug that completely protects liver from toxic materials. This study was conducted to investigate hepatoprotective effect arctigenin burdock ( Arctium lappa ) against carbon tetrachloride (CCl 4 )-induced injury. Results Arctigenin pre-administration reduced hepatotoxicity markers significantly as compared CCl group. addition, both silymarin and declined matrix metalloproteinase-2 (MMP-2) serum (1177 ± 176), (978 135) group (1734 294). The hepatic antioxidant parameters (total glutathione, superoxide dismutase, glutathione reductase) were decreased after injection, an has been prevented by arctigenin. Histological examinations illustrated damage, where it inflammation, congestion, ballooning. Conclusions exerted a -induced damage terms suppressing MMP-2 oxidative stress comparative silymarin.